Bioactive Small Molecules
Medchemexpress LLC D-Alanine, 4,4,5,5-tetradehydro-D-norvalyl-, 2,2,2-trifluoroacetate (1:1) | 87156-01-2 | 95.0% | 298.22 | 25 MG
EDA-DA TFA is a N-terminally tagged dipeptide probe that can be utilized to label Peptidoglycan (PG) of bacteria. It functions as a click chemistry reagent, possessing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. This product is intended for research use only.
- N-terminally tagged dipeptide probe
- Labels peptidoglycan (PG) of bacteria
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules
Medchemexpress LLC Eculizumab 10mg | 10mg
Eculizumab (Anti-Human C5 Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5 Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC) Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice Eculizumab can be used in hemolysis studies[1][2]
Medchemexpress LLC GCN2-IN-7 | 2396465-33-9 | C22H23BrN8OS | 5 MG
GCN2-IN-7 (compound 39) is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor with an IC50 of 5 nM. It exhibits anti-tumor activity in vivo. Research demonstrates its ability to alleviate myeloid-derived suppressive cells (MDSC)-related T cell suppression and restore T cell proliferation in CD8+ T cells. In vivo studies show robust target engagement and significant reduction of downstream marker Activation Transcription Factor 4 (ATF4), alongside inhibition of tumor growth.
- Orally active and selective GCN2 inhibitor with an IC50 of 5 nM
- Exhibits anti-tumor activity in vivo
- Alleviates MDSC-related T cell suppression and restores T cell proliferation
- Shows robust target engagement in tumor and spleen
- Reduces downstream marker Activation Transcription Factor 4 (ATF4)
- Inhibits tumor growth in a syngeneic mouse model
Medchemexpress LLC (-)-Myrtenal | 18486-69-6 | 99.1% | 150.22 | 500 MG
(-)-Myrtenal is an orally active terpene exhibiting antitumour activity. It ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. In vitro studies demonstrate a strong cytotoxic effect on human colon tumour (HT29) and normal colon epithelial cells (CCD 841 CoTr).
- Orally active terpene
- Exhibits antitumour activity
- Ameliorates hyperglycemia by enhancing GLUT2 through Akt
- Strong cytotoxic effect on human colon tumour and normal colon epithelial cells
- Decreases plasma glucose levels in diabetic rats
- Improves plasma insulin levels in diabetic rats
- Up-regulates IRS2, Akt, and GLUT2 in liver
- Up-regulates IRS2, Akt, and GLUT4 protein expression in skeletal muscle
- Appearance: liquid
- Color: colorless to light yellow
- Initial source: plants (Leguminosae Erythrina poeppigiana, Labiatae)
Cayman Chemical VnP16trIfluoroacetAT salt 5mg
A synthetic peptide fragment of vitronectin; induces attachment and cell spreading of isolated human osteogenic cells when applied to cell plates at 9.1 UG/cm2; induces osteogenesis of human skin-derived mesenchymal precursors and MC3T3-E1 mouse calvarial osteoblast precursors; decreases IL-1α-induced bone loss and decreases the number of calvarial osteoclasts in mice; increases bone mineral density and decreases trabecular bone loss in a mouse model of ovariectomy-induced bone loss
Medchemexpress LLC NRX-0492 | 2416130-57-7 | C43H51N11O6 | 100 MG
NRX-0492 is an orally active PROTAC-class BTK degrader that catalyzes BTK ubiquitination and proteasome degradation. It inhibits B cell receptor (BCR) mediated signaling, transcription programs, and chemokine secretion, demonstrating antitumor effects against chronic lymphocytic leukemia.
- Catalyzes BTK ubiquitination and proteasome degradation
- Inhibits B cell receptor (BCR) mediated signaling
- Inhibits transcription programs and chemokine secretion
- Demonstrates antitumor effects against chronic lymphocytic leukemia
- Shows high-affinity binding to wild-type and C481S/T474I mutant BTK
- Induces BTK degradation in CLL cells from blood and spleen in vivo
- Reduces proportion of Ki67+/CD69+ cells in vivo
- Decreases splenic tumor burden in CLL patient-derived xenografts
Medchemexpress LLC STING agonist-23 | 2361570-16-1 | C33H35N13O4 | 5 MG
STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. It activates STING and increases the phosphorylation of STING, TBK1, and IRF3. It promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells, and shows activity against SARS-CoV series strains.
- Activates STING, increasing the phosphorylation of STING, TBK1, and IRF3.
- Elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells.
- Demonstrates activity against SARS-CoV series strains.
- Induces a strong antibody immune response when combined with SARS-CoV-2 RBD-Fc protein in a mouse model (adjuvant activity).
Medchemexpress LLC 1H-Indole-1-carboxylic acid, octahydro-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-, methyl ester, (3aR,4S,7aR)- | 543906-09-8 | C19H23NO3 | 1 G
Mavoglurant is a potent, selective, non-competitive, and orally active mGluR5 antagonist. It is suitable for research into Fragile X syndrome (FXS) and L-dopa induced dyskinesias in Parkinson's disease. This compound also functions as a click chemistry reagent due to its alkyne group, enabling participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
- Potent, selective, non-competitive, and orally active mGluR5 antagonist
- IC50 of 30 nM for mGluR5
- Exhibits over 300-fold selectivity for mGluR5 over 238 other targets
- Suitable for research into Fragile X syndrome (FXS) and L-dopa induced dyskinesias in Parkinson's disease
- Functions as a click chemistry reagent
- Contains an alkyne group enabling participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
Selleck Chemical LLC VX-702 10mg 745833-23-2
VX-702 is a highly selective inhibitor of p38? MAPK, 14-fold higher potency against the p38? versus p38?. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC B7-H6 Human Biotin 100ug | 100ug
B7-H6 a distinctive monomeric protein uniquely triggers NCR3-dependent natural killer (NK) cell activation specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1 NCR2 and KLRK1) This specificity underscores B7-H6 s unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms B7-H6 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H6 protein expressed by HEK293 with C-His C-Avi labeled tag
Selleck Chemical LLC Nardosinone S9093-1MG
Nardosinone isolated from Nardostachys root an important Chinese herbal medicine is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects including sedative adaptogen-like anti-depressive anti-leukemic anti-tumorous and anti-trypanosomal activities
Cayman Chemical ANTIBODY ACY-738 10mg
An inhibitor of HDAC6 (IC50 = 1.7 nM); selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively); increases acetylation of α-tubulin in mouse brain at 5 mg/kg; increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice at 50 mg/kg; attenuates decreases in caudal nerve SNAP amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of vincristine-induced peripheral neuropathy at 100 mg/kg in the diet; decreases hepatorenal cystogenesis in a rat model of polycystic liver disease at 30 mg/kg
Medchemexpress LLC KB-5492 free base | 113594-64-2 | 99.02% | C23H30N2O6 | 100 MG
The compound is a potent and selective inhibitor of the sigma receptor. It inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. It also functions as an anti-ulcer agent.
- Sigma receptor inhibition: It is a potent and selective inhibitor of the sigma receptor, showing an IC50 of 3.15 μM for sigma receptor binding.
- Anti-ulcer agent: The compound has been identified as an anti-ulcer agent.
- In vitro activity: It inhibits specific [3H]DTG binding in a concentration-dependent manner. It also significantly and concentration-dependently prevents ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.
- In vivo activity: When administered orally at 200 mg/kg, it prevents macroscopic lesions in the gastric mucosa, reducing lesion length and preventing deep mucosal lesions and exfoliation of surface epithelial cells in animal models.
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | 10 G
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties, acting as a mechanism-based inhibitor for CYP2A6. It significantly reduces alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage. It also restores total protein (TP) and albumin (TA) levels in serum, prevents oxidative stress, and can decrease the mitotic activity of *A. sativum* promeristem.
- Acts as a mechanism-based inhibitor for human CYP2A6.
- Can induce chromosomal aberrations in *A. sativum* promeristem.
- Restores elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in rats.
- Restores antioxidant enzyme and TBARS levels.
- Restores serum bilirubin (TB) and total protein (TP) levels.
- Reduces hepatic lesions induced by CCl4.
Medchemexpress LLC Isosorbide mononitrate | 16051-77-7 | 1 G
Isosorbide mononitrate | 16051-77-7 | 1 G